Exploratory visual analysis of conserved domains on multiple sequence alignments.

ABSTRACT:

Background

Multiple alignment of protein sequences can provide insight into sequence conservation across many species and thus allow identification of those sections of the sequence most critical to protein function. This insight can be augmented by joint display of conserved domains along the sequences. By fusing this metadata visually, biologists can analyze sequence conservation and functional motifs simultaneously and efficiently.

Results

We present MSAVis, a new approach combining luminance and hue for simultaneous visualization of conserved motifs and sequence alignment. Input for the algorithm is a multiple sequence alignment in a standard format. The NCBI Conserved Domain Database (CDD) is used for finding conserved domains along the alignment. The visualization quic

SUBMITTER: Jankun-Kelly TJ 

PROVIDER: S-EPMC3226196 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature