Ontology highlight
ABSTRACT:
SUBMITTER: Elegheert J
PROVIDER: S-EPMC3260422 | biostudies-literature | 2011 Dec
REPOSITORIES: biostudies-literature
Elegheert Jonathan J Desfosses Ambroise A Shkumatov Alexander V AV Wu Xiongwu X Bracke Nathalie N Verstraete Kenneth K Van Craenenbroeck Kathleen K Brooks Bernard R BR Svergun Dmitri I DI Vergauwen Bjorn B Gutsche Irina I Savvides Savvas N SN
Structure (London, England : 1993) 20111201 12
The hematopoietic colony stimulating factor-1 receptor (CSF-1R or FMS) is essential for the cellular repertoire of the mammalian immune system. Here, we report a structural and mechanistic consensus for the assembly of human and mouse CSF-1:CSF-1R complexes. The EM structure of the complete extracellular assembly of the human CSF-1:CSF-1R complex reveals how receptor dimerization by CSF-1 invokes a ternary complex featuring extensive homotypic receptor contacts and striking structural plasticity ...[more]