COUP-TFII controls mouse pancreatic β-cell mass through GLP-1-β-catenin signaling pathways.

ABSTRACT:

Background

The control of the functional pancreatic β-cell mass serves the key homeostatic function of releasing the right amount of insulin to keep blood sugar in the normal range. It is not fully understood though how β-cell mass is determined.

Methodology/principal findings

Conditional chicken ovalbumin upstream promoter transcription factor II (COUP-TFII)-deficient mice were generated and crossed with mice expressing Cre under the control of pancreatic duodenal homeobox 1 (pdx1) gene promoter. Ablation of COUP-TFII in pancreas resulted in glucose intolerance. Beta-cell number was reduced at 1 day and 3 weeks postnatal. Together with a reduced number of insulin-containing cells in the ductal epithelium and normal β-cell proliferation and apoptosis, this suggests decreased

SUBMITTER: Boutant M 

PROVIDER: S-EPMC3265526 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature