Dataset Information

Polymorphism in apoA1 Influences High-Density Lipoprotein Cholesterol Levels but Is Not a Major Risk Factor of Alzheimer's Disease.

ABSTRACT:

Background

Apolipoprotein A1 (apoA1) is the major apolipoprotein constituent of the high-density lipoprotein (HDL) and is involved in reverse cholesterol transport. Variation in the apoA1 gene might influence the function of the protein and, thus, brain cholesterol metabolism, leading to an increased risk for Alzheimer's disease (AD).

Aim

In the current report, we investigated the role of the functional apoA1 polymorphism (-75 G/A) as a genetic risk factor for AD in a Tunisian population.

Methods

173 AD patients and 150 healthy controls were studied.

Results

No association was found between this genetic variation in apoA1 gene and the risk of AD. The presence of the (-75 G/A) A allele appeared, however, to be associated with lower levels of cerebrospinal fluid Aβ42 and HDL cholesterol levels in sera.

Conclusion

Our data support the observation that apoA1 polymorphism influences cholesterol metabolism and Aβ42 deposition in the brain.

SUBMITTER: Smach MA

PROVIDER: S-EPMC3270813 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature

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Publications

Polymorphism in apoA1 Influences High-Density Lipoprotein Cholesterol Levels but Is Not a Major Risk Factor of Alzheimer's Disease.

Smach Mohamed Ali MA Edziri Hayet H Charfeddine Bassem B Ben Othman Leila L Lammouchi Turkia T Ltaief Afef A Nafati Souhir S Dridi Hedi H Bennamou Soufien S Limem Khalifa K

Dementia and geriatric cognitive disorders extra 20110101 1

<h4>Background</h4>Apolipoprotein A1 (apoA1) is the major apolipoprotein constituent of the high-density lipoprotein (HDL) and is involved in reverse cholesterol transport. Variation in the apoA1 gene might influence the function of the protein and, thus, brain cholesterol metabolism, leading to an increased risk for Alzheimer's disease (AD).<h4>Aim</h4>In the current report, we investigated the role of the functional apoA1 polymorphism (-75 G/A) as a genetic risk factor for AD in a Tunisian pop ...[more]

PMID: 22323901

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Dataset Information

Polymorphism in apoA1 Influences High-Density Lipoprotein Cholesterol Levels but Is Not a Major Risk Factor of Alzheimer's Disease.

Background

Aim

Methods

Results

Conclusion

Publications

Polymorphism in apoA1 Influences High-Density Lipoprotein Cholesterol Levels but Is Not a Major Risk Factor of Alzheimer's Disease.

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