Topiramate dose effects on cognition: a randomized double-blind study.

ABSTRACT:

Background

Topiramate (TPM), a broad-spectrum antiepileptic drug, has been associated with neuropsychological impairment in patients with epilepsy and in healthy volunteers.

Objective

To establish whether TPM-induced neuropsychological impairment emerges in a dose-dependent fashion and whether early cognitive response (6-week) predicts later performance (24-week).

Methods

Computerized neuropsychological assessment was performed on 188 cognitively normal adults who completed a double-blind, placebo-controlled, parallel-group, 24-week, dose-ranging study which was designed primarily to assess TPM effects on weight. Target doses were 64, 96, 192, or 384 mg per day. The Computerized Neuropsychological Test Battery was administered at baseline and 6, 12, and 24 weeks. Indi

SUBMITTER: Loring DW 

PROVIDER: S-EPMC3271389 | biostudies-literature | 2011 Jan

REPOSITORIES: biostudies-literature