The utility of Aspirin in Dukes C and High Risk Dukes B Colorectal cancer--the ASCOLT study: study protocol for a randomized controlled trial.

ABSTRACT:

Background

High quality evidence indicates that aspirin is effective in reducing colorectal polyps; and numerous epidemiological studies point towards an ability to prevent colorectal cancer. However the role of Aspirin as an adjuvant agent in patients with established cancers remains to be defined. Recently a nested case-control study within the Nurses Health cohort suggested that the initiation of Aspirin after the diagnosis of colon cancer reduced overall colorectal cancer specific mortality. Although this data is supportive of Aspirin's biological activity in this disease and possible role in adjuvant therapy, it needs to be confirmed in a randomized prospective trial.

Methods/design

We hypothesize through this randomized, placebo-controlled adjuvant study, that Aspirin

SUBMITTER: Ali R 

PROVIDER: S-EPMC3271983 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature