Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice.

ABSTRACT: The leading cause of death in diabetic patients is cardiovascular disease; diabetic cardiomyopathy is typified by alterations in cardiac morphology and function, independent of hypertension or coronary disease. However, the molecular mechanism that links diabetes to cardiomyopathy is incompletely understood. Insulin resistance is a hallmark feature of diabetes, and the FoxO family of transcription factors, which regulate cell size, viability, and metabolism, are established targets of insulin and growth factor signaling. Here, we set out to evaluate a possible role of FoxO proteins in diabetic cardiomyopathy. We found that FoxO proteins were persistently activated in cardiac tissue in mice with diabetes induced either genetically or by high-fat diet (HFD). FoxO activity was critically link

SUBMITTER: Battiprolu PK 

PROVIDER: S-EPMC3287230 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature