Urolithin A ameliorates obesity-induced metabolic cardiomyopathy in mice via mitophagy activation.

ABSTRACT: Metabolic cardiomyopathy (MC) is characterized by intracellular lipid accumulation and utilizing fatty acids as a foremost energy source, thereby leading to excess oxidative stress and mitochondrial dysfunction. There is no effective therapy available yet. In this study we investigated whether defective mitophagy contributed to MC and whether urolithin A (UA), a naturally occurring microflora-derived metabolite, could protect against MC in experimental obese mice. Mice were fed high fat diet for 20 weeks to establish a diet-induced obese model. We showed that mitochondrial autophagy or mitophagy was significantly downregulated in the heart of experimental obese mice. UA (50 mg·kg^-1·d^-1, for 4 weeks) markedly activated mitophagy and ameliorated MC in obese mice by gava

SUBMITTER: Huang JR 

PROVIDER: S-EPMC9889402 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature