Supernatants derived from chemotherapy-treated cancer cell lines can modify angiogenesis.

ABSTRACT:

Background

There is evidence that tumours produce substances such as cytokines and microvesicular bodies bearing bioactive molecules, which support the carcinogenic process. Furthermore, chemotherapy has also been shown to modify these exudates and in doing so, neutralise their tumourigenic influence.

Methods

In the current study, we have investigated the effect of chemotherapy agents on modifying the cytokine profile and microvesicular cargo of supernatants derived from cancer cell lines. In addition, we have explored the effect of these tumour-derived supernatants on angiogenesis, and how chemotherapy can alter the supernatants rendering them less pro-angiogenic.

Results

Herein, we show that supernatants contain a rich cocktail of cytokines, a number of which are po

SUBMITTER: Liu WM 

PROVIDER: S-EPMC3305950 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature