Dataset Information
SynaptomeDB: an ontology-based knowledgebase for synaptic genes.
Ontology highlight
ABSTRACT: Motivation
The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.Results
We present an integrated database, called SynaptomeDB, to retrieve and annotate genes comprising the synaptome. These genes encode components of the synapse including neurotransmitters and their receptors, adhesion/cytoskeletal proteins, scaffold proteins, membrane transporters. SynaptomeDB integrates various and complex data sources for synaptic genes and proteins.
SUBMITTER: Pirooznia M
PROVIDER: S-EPMC3307115 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
SynaptomeDB: an ontology-based knowledgebase for synaptic genes.
Bioinformatics (Oxford, England) 20120127 6
<h4>Motivation</h4>The synapse is integral to the function of the brain and may be an important source of dysfunction underlying many neuropsychiatric disorders. Consequently, it is an excellent candidate for large-scale genomic and proteomic study. However, while the tools and databases available for the annotation of high-throughput DNA and protein are generally robust, a comprehensive resource dedicated to the integration of information about the synapse is lacking.<h4>Results</h4>We present ...[more]