The identification of short linear motif-mediated interfaces within the human interactome.

ABSTRACT:

Motivation

Eukaryotic proteins are highly modular, containing multiple interaction interfaces that mediate binding to a network of regulators and effectors. Recent advances in high-throughput proteomics have rapidly expanded the number of known protein-protein interactions (PPIs); however, the molecular basis for the majority of these interactions remains to be elucidated. There has been a growing appreciation of the importance of a subset of these PPIs, namely those mediated by short linear motifs (SLiMs), particularly the canonical and ubiquitous SH2, SH3 and PDZ domain-binding motifs. However, these motif classes represent only a small fraction of known SLiMs and outside these examples little effort has been made, either bioinformatically or experimentally, to discover the full

SUBMITTER: Weatheritt RJ 

PROVIDER: S-EPMC3315716 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature