Ontology highlight
ABSTRACT:
SUBMITTER: Dall'Armi C
PROVIDER: S-EPMC3328354 | biostudies-literature | 2010
REPOSITORIES: biostudies-literature
Nature communications 20100101
Although macroautophagy is known to be an essential degradative process whereby autophagosomes mediate the engulfment and delivery of cytoplasmic components into lysosomes, the lipid changes underlying autophagosomal membrane dynamics are undetermined. Here, we show that phospholipase D1 (PLD1), which is primarily associated with the endosomal system, partially relocalizes to the outer membrane of autophagosome-like structures upon nutrient starvation. The localization of PLD1, as well as the st ...[more]