ADRB3 polymorphism associated with BMI gain in Japanese men.

ABSTRACT:

Objective

The aim of this study was to evaluate the association between the Trp64Arg polymorphism in the beta3-adrenergic receptor gene (ADRB3: rs4994) and BMI and serological and anthropometric data in healthy Japanese.

Methods

Healthy Japanese recruited in a large-scale integrated manufacturing facility in Japan (N = 1355; age: 37.25 ± 9.43; BMI: 22.86 ± 3.46) were eligible for analysis. The anthropometric data and serological data were measured during a comprehensive health check, and a self-reporting questionnaire was used to assess lifestyle habits (current exercise, smoking status, alcohol intake, and working style) and weight at age 20. Genotyping for the ADRB3 polymorphism was performed by PCR-RFLP method.

Results

Among 1355 participants, the genotype frequenc

SUBMITTER: Takeuchi S 

PROVIDER: S-EPMC3328897 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature