Isoflurane delays the development of early brain injury after subarachnoid hemorrhage through sphingosine-related pathway activation in mice.

ABSTRACT:

Objective

Isoflurane, a volatile anesthetic agent, has been recognized for its potential neuroprotective properties and has antiapoptotic effects. We examined whether isoflurane posttreatment is protective against early brain injury after subarachnoid hemorrhage and determined whether this effect needs sphingosine-related pathway activation.

Design

Controlled in vivo laboratory study.

Setting

Animal research laboratory.

Subjects

One hundred seventy-nine 8-wk-old male CD-1 mice weighing 30-38 g.

Interventions

Subarachnoid hemorrhage was induced in mice by endovascular perforation. Animals were randomly assigned to sham-operated, subarachnoid hemorrhage-vehicle, and subarachnoid hemorrhage+2% isoflurane. Neurobehavioral function and brain edema were evalua

SUBMITTER: Altay O 

PROVIDER: S-EPMC3358576 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature