Ontology highlight
ABSTRACT:
SUBMITTER: Danzer KM
PROVIDER: S-EPMC3364517 | biostudies-literature | 2011 Sep
REPOSITORIES: biostudies-literature
Danzer Karin M KM McLean Pamela J PJ
CNS & neurological disorders drug targets 20110901 6
One of the critical issues in Parkinson disease (PD) research is the identity of the specific toxic, pathogenic moiety. In PD, mutations in α-synuclein (αsyn) or multiplication of the SNCA gene encoding αsyn, result in a phenotype of cellular inclusions, cell death, and brain dysfunction. While the historical point of view has been that the macroscopic aggregates containing αsyn are the toxic species, in the last several years evidence has emerged that suggests instead that smaller soluble speci ...[more]