Genome-wide association identifies the T gene as a novel asthma pharmacogenetic locus.

ABSTRACT:

Rationale

To date, most studies aimed at discovering genetic factors influencing treatment response in asthma have focused on biologic candidate genes. Genome-wide association studies (GWAS) can rapidly identify novel pharmacogenetic loci.

Objectives

To investigate if GWAS can identify novel pharmacogenetic loci in asthma.

Methods

Using phenotypic and GWAS genotype data available through the NHLBI-funded Single-nucleotide polymorphism Health association-Asthma Resource Project, we analyzed differences in FEV(1) in response to inhaled corticosteroids in 418 white subjects with asthma. Of the 444,088 single nucleotide polymorphisms (SNPs) analyzed, the lowest 50 SNPs by P value were genotyped in an independent clinical trial population of 407 subjects with asthma.

Me

SUBMITTER: Tantisira KG 

PROVIDER: S-EPMC3381232 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature