Ontology highlight
ABSTRACT:
SUBMITTER: Pickard A
PROVIDER: S-EPMC3400012 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
The EMBO journal 20120529 14
Stromal-derived growth factors are required for normal epithelial growth but are also implicated in tumour progression. We have observed inactivation of the retinoblastoma protein (Rb), through phosphorylation, in cancer-associated fibroblasts in oro-pharyngeal cancer specimens. Rb is well known for its cell-autonomous effects on cancer initiation and progression; however, cell non-autonomous functions of Rb are not well described. We have identified a cell non-autonomous role of Rb, using three ...[more]