Ontology highlight
ABSTRACT:
SUBMITTER: Schmid M
PROVIDER: S-EPMC3408791 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20120607 2
Poly(A) (pA) tail binding proteins (PABPs) control mRNA polyadenylation, stability, and translation. In a purified system, S. cerevisiae PABPs, Pab1p and Nab2p, are individually sufficient to provide normal pA tail length. However, it is unknown how this occurs in more complex environments. Here we find that the nuclear exosome subunit Rrp6p counteracts the in vitro and in vivo extension of mature pA tails by the noncanonical pA polymerase Trf4p. Moreover, PABP loading onto nascent pA tails is c ...[more]