On the prospects of whole-genome association mapping in Saccharomyces cerevisiae.

ABSTRACT: Advances in sequencing technology have enabled whole-genome sequences to be obtained from multiple individuals within species, particularly in model organisms with compact genomes. For example, 36 genome sequences of Saccharomyces cerevisiae are now publicly available, and SNP data are available for even larger collections of strains. One potential use of these resources is mapping the genetic basis of phenotypic variation through genome-wide association (GWA) studies, with the benefit that associated variants can be studied experimentally with greater ease than in outbred populations such as humans. Here, we evaluate the prospects of GWA studies in S. cerevisiae strains through extensive simulations and a GWA study of mitochondrial copy number. We demonstrate that the complex and heteroge

SUBMITTER: Connelly CF 

PROVIDER: S-EPMC3416012 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature