Ontology highlight
ABSTRACT:
SUBMITTER: Fowler TW
PROVIDER: S-EPMC3419249 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Fowler Tristan W TW McKelvey Kent D KD Akel Nisreen S NS Vander Schilden Jaclyn J Bacon Anthony W AW Bracey John W JW Sowder Timothy T Skinner Robert A RA Swain Frances L FL Hogue William R WR Leblanc Donna B DB Gaddy Dana D Wenger Galen R GR Suva Larry J LJ
PloS one 20120814 8
Trisomy 21 affects virtually every organ system and results in the complex clinical presentation of Down syndrome (DS). Patterns of differences are now being recognized as patients' age and these patterns bring about new opportunities for disease prevention and treatment. Low bone mineral density (BMD) has been reported in many studies of males and females with DS yet the specific effects of trisomy 21 on the skeleton remain poorly defined. Therefore we determined the bone phenotype and measured ...[more]