Receptor diversity and host interaction of bacteriophages infecting Salmonella enterica serovar Typhimurium.

ABSTRACT:

Background

Salmonella enterica subspecies enterica serovar Typhimurium is a gram-negative pathogen causing salmonellosis. Salmonella Typhimurium-targeting bacteriophages have been proposed as an alternative biocontrol agent to antibiotics. To further understand infection and interaction mechanisms between the host strains and the bacteriophages, the receptor diversity of these phages needs to be elucidated.

Methodology/principal findings

Twenty-five Salmonella phages were isolated and their receptors were identified by screening a Tn5 random mutant library of S. Typhimurium SL1344. Among them, three types of receptors were identified flagella (11 phages), vitamin B(12) uptake outer membrane protein, BtuB (7 phages) and lipopolysaccharide-related O-antigen (7 phages). TEM obs

SUBMITTER: Shin H 

PROVIDER: S-EPMC3424200 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature