The transcriptional programme controlled by Runx1 during early embryonic blood development.

ABSTRACT: Transcription factors have long been recognised as powerful regulators of mammalian development yet it is largely unknown how individual key regulators operate within wider regulatory networks. Here we have used a combination of global gene expression and chromatin-immunoprecipitation approaches during the early stages of haematopoietic development to define the transcriptional programme controlled by Runx1, an essential regulator of blood cell specification. Integrated analysis of these complementary genome-wide datasets allowed us to construct a global regulatory network model, which suggested that key regulators are activated sequentially during blood specification, but will ultimately collaborate to control many haematopoietically expressed genes. Using the CD41/integrin alpha 2b gene

SUBMITTER: Tanaka Y 

PROVIDER: S-EPMC3430866 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature