Ontology highlight
ABSTRACT:
SUBMITTER: Marchand A
PROVIDER: S-EPMC3432110 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Marchand Alexandre A Proust Carole C Morange Pierre-Emmanuel PE Lompré Anne-Marie AM Trégouët David-Alexandre DA
PloS one 20120831 8
In this work, we assessed whether SERPINE1 expression could be under the influence of microRNAs (miRNAs) predicted to bind the SERPINE1 3'UTR region. We specifically focused on the 3'UTR region harboring a common polymorphism, rs1050955, that have been found associated to SERPINE1 monocyte expression, and investigated whether the presence of different alleles at rs1050955 could modify the miRNAs binding efficiency and affect PAI-1 protein levels. We demonstrated that, in human umbilical vein end ...[more]