Risk estimation and risk prediction using machine-learning methods.
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ABSTRACT:
SUBMITTER: Kruppa J
PROVIDER: S-EPMC3432206 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Risk estimation and risk prediction using machine-learning methods.
Kruppa Jochen J Ziegler Andreas A König Inke R IR
Human genetics 20120703 10
After an association between genetic variants and a phenotype has been established, further study goals comprise the classification of patients according to disease risk or the estimation of disease probability. To accomplish this, different statistical methods are required, and specifically machine-learning approaches may offer advantages over classical techniques. In this paper, we describe methods for the construction and evaluation of classification and probability estimation rules. We revie ...[more]
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