A multicenter study confirms CD226 gene association with systemic sclerosis-related pulmonary fibrosis.

ABSTRACT:

Introduction

CD226 genetic variants have been associated with a number of autoimmune diseases and recently with systemic sclerosis (SSc). The aim of this study was to test the influence of CD226 loci in SSc susceptibility, clinical phenotypes and autoantibody status in a large multicenter European population.

Methods

A total of seven European populations of Caucasian ancestry were included, comprising 2,131 patients with SSc and 3,966 healthy controls. Three CD226 single nucleotide polymorphisms (SNPs), rs763361, rs3479968 and rs727088, were genotyped using Taqman 5'allelic discrimination assays.

Results

Pooled analyses showed no evidence of association of the three SNPs, neither with the global disease nor with the analyzed subphenotypes. However, haplotype block ana

SUBMITTER: Bossini-Castillo L 

PROVIDER: S-EPMC3446459 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature