Clinical parameters model for predicting pathologic complete response following preoperative chemoradiation in patients with esophageal cancer.

ABSTRACT:

Background

Approximately 25% of patients with esophageal cancer (EC) who undergo preoperative chemoradiation, achieve a pathologic complete response (pathCR). We hypothesized that a model based on clinical parameters could predict pathCR with a high (≥60%) probability.

Patients and methods

We analyzed 322 patients with EC who underwent preoperative chemoradiation. All the patients had baseline and postchemoradiation positron emission tomography (PET) and pre- and postchemoradiation endoscopic biopsy. Logistic regression models were used for analysis, and cross-validation via the bootstrap method was carried out to test the model.

Results

The 70 (21.7%) patients who achieved a pathCR lived longer (median overall survival [OS], 79.76 months) than the 252 patients who di

SUBMITTER: Ajani JA 

PROVIDER: S-EPMC3457750 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature