SOD mimetic improves the function, growth, and survival of small-size liver grafts after transplantation in rats.

ABSTRACT:

Background

Small-for-size syndrome (SFSS) may occur when graft volume is less than 45% of the standard liver volume, and it manifests as retarded growth and failure of the grafts and more mortality. However, its pathogenesis is poorly understood, and few effective interventions have been attempted.

Aims

The present study aimed to delineate the critical role of oxidant stress in SFSS and protective effects of a superoxide dismutase mimetic, Mn(III)tetrakis(4-benzoic acid)porphyrin chloride (MnTBAP), on graft function, growth, and survival in the recipient rats.

Methods

Small size graft liver transplantation (SSGLT) was performed to determine the survival, graft injury, and growth. MnTBAP was administered in SSGLT recipients (SSGLT+MnTBAP).

Results

Serum alanine

SUBMITTER: Cui YY 

PROVIDER: S-EPMC3465521 | biostudies-literature | 2012 Oct

REPOSITORIES: biostudies-literature