Clinical and biomarker changes in dominantly inherited Alzheimer's disease.

ABSTRACT:

Background

The order and magnitude of pathologic processes in Alzheimer's disease are not well understood, partly because the disease develops over many years. Autosomal dominant Alzheimer's disease has a predictable age at onset and provides an opportunity to determine the sequence and magnitude of pathologic changes that culminate in symptomatic disease.

Methods

In this prospective, longitudinal study, we analyzed data from 128 participants who underwent baseline clinical and cognitive assessments, brain imaging, and cerebrospinal fluid (CSF) and blood tests. We used the participant's age at baseline assessment and the parent's age at the onset of symptoms of Alzheimer's disease to calculate the estimated years from expected symptom onset (age of the participant minus pare

SUBMITTER: Bateman RJ 

PROVIDER: S-EPMC3474597 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature