Proliferation and tissue remodeling in cancer: the hallmarks revisited.
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ABSTRACT:
SUBMITTER: Markert EK
PROVIDER: S-EPMC3481128 | biostudies-literature | 2012 Oct
REPOSITORIES: biostudies-literature
Publications
Proliferation and tissue remodeling in cancer: the hallmarks revisited.
Markert E K EK Levine A J AJ Vazquez A A
Cell death & disease 20121004
Although cancers are highly heterogeneous at the genomic level, they can manifest common patterns of gene expression. Here, we use gene expression signatures to interrogate two major processes in cancer, proliferation and tissue remodeling. We demonstrate that proliferation and remodeling signatures are partially independent and result in four distinctive cancer subtypes. Cancers with the proliferation signature are characterized by signatures of p53 and PTEN inactivation and concomitant Myc act ...[more]
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