Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers.

ABSTRACT:

Context

Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968.

Objective

To determine whether the association between rs16969968 and smoking is modified by age at onset of regular smoking.

Data sources

Primary data.

Study selection

Available genetic studies containing measures of CPD and the genotype of rs16969968 or its proxy.

Data extraction

Uniform statistical analysis scripts were run locally. Starting with 94,050 ever-smokers from 43 studies, we extracted the heavy smokers (CPD >20) and light smokers (CPD ≤10) with age-at-onset information, reducing the sample size to 33,348. Each study was stratified into early-onset smokers (age at onset ≤16 years) and lat

SUBMITTER: Hartz SM 

PROVIDER: S-EPMC3482121 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature