The tight junction protein claudin-1 influences cranial neural crest cell emigration.

ABSTRACT: The neural crest is a population of migratory cells that follows specific pathways during development, eventually differentiating to form parts of the face, heart, and peripheral nervous system, the latter of which includes contributions from placodal cells derived from the ectoderm. Stationary, premigratory neural crest cells acquire the capacity to migrate by undergoing an epithelial-to-mesenchymal transition that facilitates their emigration from the dorsal neural tube. This emigration involves, in part, the dismantling of cell-cell junctions, including apically localized tight junctions in the neuroepithelium. In this study, we have characterized the role of the transmembrane tight junction protein claudin-1 during neural crest and placode ontogeny. Our data indicate that claudin-1 is

SUBMITTER: Fishwick KJ 

PROVIDER: S-EPMC3482127 | biostudies-literature | 2012 Sep-Dec

REPOSITORIES: biostudies-literature