Genome characterisation of the genus Francisella reveals insight into similar evolutionary paths in pathogens of mammals and fish.

ABSTRACT:

Background

Prior to this study, relatively few strains of Francisella had been genome-sequenced. Previously published Francisella genome sequences were largely restricted to the zoonotic agent F. tularensis. Only limited data were available for other members of the Francisella genus, including F. philomiragia, an opportunistic pathogen of humans, F. noatunensis, a serious pathogen of farmed fish, and other less well described endosymbiotic species.

Results

We determined the phylogenetic relationships of all known Francisella species, including some for which the phylogenetic positions were previously uncertain. The genus Francisella could be divided into two main genetic clades: one included F. tularensis, F. novicida, F. hispaniensis and Wolbachia persica, and another inclu

SUBMITTER: Sjodin A 

PROVIDER: S-EPMC3485624 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature