Hidden evolutionary complexity of Nucleo-Cytoplasmic Large DNA viruses of eukaryotes.

ABSTRACT:

Background

The Nucleo-Cytoplasmic Large DNA Viruses (NCLDV) constitute an apparently monophyletic group that consists of at least 6 families of viruses infecting a broad variety of eukaryotic hosts. A comprehensive genome comparison and maximum-likelihood reconstruction of the NCLDV evolution revealed a set of approximately 50 conserved, core genes that could be mapped to the genome of the common ancestor of this class of eukaryotic viruses.

Results

We performed a detailed phylogenetic analysis of these core NCLDV genes and applied the constrained tree approach to show that the majority of the core genes are unlikely to be monophyletic. Several of the core genes have been independently acquired from different sources by different NCLDV lineages whereas for the majority of th

SUBMITTER: Yutin N 

PROVIDER: S-EPMC3493329 | biostudies-literature | 2012 Aug

REPOSITORIES: biostudies-literature