Glycine transporter-1 inhibition preceding extinction training inhibits reacquisition of cocaine seeking.

ABSTRACT: Cognitive enhancers that act by increasing glycine transmission might be useful adjuncts to cocaine-cue extinction training to deter relapse. The study investigated the effects of combining treatments of the glycine transporter-1 (GlyT-1) inhibitor, Org24598, with extinction training on the subsequent reacquisition of cocaine self-administration. Squirrel monkeys and rats were trained to self-administer cocaine under a second-order schedule of intravenous drug injection in which responding was maintained by cocaine injections and a cocaine-paired visual stimulus. During three weekly extinction sessions, saline was substituted for cocaine but responding still produced the cocaine-paired stimulus. Subjects were treated with Org24598 or vehicle, either before or after each extinction session.

SUBMITTER: Achat-Mendes C 

PROVIDER: S-EPMC3499725 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature