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Synthetic studies towards bottromycin.

ABSTRACT: Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.

SUBMITTER: Ackermann S

PROVIDER: S-EPMC3510998 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Synthetic studies towards bottromycin.

Ackermann Stefanie S Lerchen Hans-Georg HG Häbich Dieter D Ullrich Angelika A Kazmaier Uli U

Beilstein journal of organic chemistry 20121001

Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner. ...[more]

PMID: 23209498

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