Synthetic studies towards bottromycin.

ABSTRACT: Thio-Ugi reactions are described as an excellent synthetic tool for the synthesis of sterically highly hindered endothiopeptides. S-Methylation and subsequent amidine formation can be carried out in an inter- as well as in an intramolecular fashion. The intramolecular approach allows the synthesis of the bottromycin ring system in a straightforward manner.

SUBMITTER: Ackermann S 

PROVIDER: S-EPMC3510998 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature