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Diffusion tensor imaging-based characterization of brain neurodevelopment in primates.


ABSTRACT: Primate neuroimaging provides a critical opportunity for understanding neurodevelopment. Yet the lack of a normative description has limited the direct comparison with changes in humans. This paper presents for the first time a cross-sectional diffusion tensor imaging (DTI) study characterizing primate brain neurodevelopment between 1 and 6 years of age on 25 healthy undisturbed rhesus monkeys (14 male, 11 female). A comprehensive analysis including region-of-interest, voxel-wise, and fiber tract-based approach demonstrated significant changes of DTI properties over time. Changes in fractional anisotropy (FA), mean diffusivity, axial diffusivity (AD), and radial diffusivity (RD) exhibited a heterogeneous pattern across different regions as well as along fiber tracts. Most of these patterns are similar to those from human studies yet a few followed unique patterns. Overall, we observed substantial increase in FA and AD and a decrease in RD for white matter (WM) along with similar yet smaller changes in gray matter (GM). We further observed an overall posterior-to-anterior trend in DTI property changes over time and strong correlations between WM and GM development. These DTI trends provide crucial insights into underlying age-related biological maturation, including myelination, axonal density changes, fiber tract reorganization, and synaptic pruning processes.

SUBMITTER: Shi Y 

PROVIDER: S-EPMC3513950 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Diffusion tensor imaging-based characterization of brain neurodevelopment in primates.

Shi Yundi Y   Short Sarah J SJ   Knickmeyer Rebecca C RC   Wang Jiaping J   Coe Christopher L CL   Niethammer Marc M   Gilmore John H JH   Zhu Hongtu H   Styner Martin A MA  

Cerebral cortex (New York, N.Y. : 1991) 20120123 1


Primate neuroimaging provides a critical opportunity for understanding neurodevelopment. Yet the lack of a normative description has limited the direct comparison with changes in humans. This paper presents for the first time a cross-sectional diffusion tensor imaging (DTI) study characterizing primate brain neurodevelopment between 1 and 6 years of age on 25 healthy undisturbed rhesus monkeys (14 male, 11 female). A comprehensive analysis including region-of-interest, voxel-wise, and fiber tract-  ...[more]

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