Levels of 25-hydroxyvitamin D in familial longevity: the Leiden Longevity Study.

ABSTRACT:

Background

Low levels of 25(OH) vitamin D are associated with various age-related diseases and mortality, but causality has not been determined. We investigated vitamin D levels in the offspring of nonagenarians who had at least one nonagenarian sibling; these offspring have a lower prevalence of age-related diseases and a higher propensity to reach old age compared with their partners.

Methods

We assessed anthropometric characteristics, 25(OH) vitamin D levels, parathyroid hormone levels, dietary vitamin D intake and single nucleotide polymorphisms (SNPs) associated with vitamin D levels. We included offspring (n = 1038) of nonagenarians who had at least one nonagenarian sibling, and the offsprings' partners (n = 461; controls) from the Leiden Longevity Study. We included a

SUBMITTER: Noordam R 

PROVIDER: S-EPMC3519162 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature