Dataset Information

Contribution of screening and survival differences to racial disparities in colorectal cancer rates.

ABSTRACT:

Background

Considerable disparities exist in colorectal cancer (CRC) incidence and mortality rates between blacks and whites in the United States. We estimated how much of these disparities could be explained by differences in CRC screening and stage-specific relative CRC survival.

Methods

We used the MISCAN-Colon microsimulation model to estimate CRC incidence and mortality rates in blacks, aged 50 years and older, from 1975 to 2007 assuming they had: (i) the same trends in screening rates as whites instead of observed screening rates (incidence and mortality); (ii) the same trends in stage-specific relative CRC survival rates as whites instead of observed (mortality only); and (iii) a combination of both. The racial disparities in CRC incidence and mortality rates attributable to differences in screening and/or stage-specific relative CRC survival were then calculated by comparing rates from these scenarios to the observed black rates.

Results

Differences in screening accounted for 42% of disparity in CRC incidence and 19% of disparity in CRC mortality between blacks and whites. Thirty-six percent of the disparity in CRC mortality could be attributed to differences in stage-specific relative CRC survival. Together screening and survival explained a little more than 50% of the disparity in CRC mortality between blacks and whites.

Conclusion

Differences in screening and relative CRC survival are responsible for a considerable proportion of the observed disparities in CRC incidence and mortality rates between blacks and whites.

Impact

Enabling blacks to achieve equal access to care as whites could substantially reduce the racial disparities in CRC burden.

SUBMITTER: Lansdorp-Vogelaar I

PROVIDER: S-EPMC3531983 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Contribution of screening and survival differences to racial disparities in colorectal cancer rates.

Lansdorp-Vogelaar Iris I Kuntz Karen M KM Knudsen Amy B AB van Ballegooijen Marjolein M Zauber Ann G AG Jemal Ahmedin A

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 20120418 5

<h4>Background</h4>Considerable disparities exist in colorectal cancer (CRC) incidence and mortality rates between blacks and whites in the United States. We estimated how much of these disparities could be explained by differences in CRC screening and stage-specific relative CRC survival.<h4>Methods</h4>We used the MISCAN-Colon microsimulation model to estimate CRC incidence and mortality rates in blacks, aged 50 years and older, from 1975 to 2007 assuming they had: (i) the same trends in scree ...[more]

PMID: 22514249

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Dataset Information

Contribution of screening and survival differences to racial disparities in colorectal cancer rates.

Background

Methods

Results

Conclusion

Impact

Publications

Contribution of screening and survival differences to racial disparities in colorectal cancer rates.

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