Bone-specific overexpression of NPY modulates osteogenesis.

ABSTRACT:

Objectives

Neuropeptide Y (NPY) is a peptide involved in the regulation of appetite and energy homeostasis. Genetic data indicates that NPY decreases bone formation via central and peripheral activities. NPY is produced by various cell types including osteocytes and osteoblasts and there is evidence suggesting that peripheral NPY is important for regulation of bone formation. We sought to investigate the role of bone-derived NPY in bone metabolism.

Methods

We generated a mouse where NPY was over-expressed specifically in mature osteoblasts and osteocytes (Col2.3NPY) and characterized the bone phenotype of these mice in vivo and in vitro.

Results

Trabecular and cortical bone volume was reduced in 3-month-old animals, however bone formation rate and osteoclast activity

SUBMITTER: Matic I 

PROVIDER: S-EPMC3558927 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature