Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors.

ABSTRACT: In response to three highly conserved neuropeptides, neuropeptide Y (NPY), peptide YY, and pancreatic polypeptide (PP), four G protein-coupled receptors mediate multiple essential physiological processes, such as food intake, vasoconstriction, sedation, and memory retention. Here, we report the structures of the human Y₁, Y₂, and Y₄ receptors in complex with NPY or PP, and the G_i1 protein. These structures reveal distinct binding poses of the peptide upon coupling to different receptors, reflecting the importance of the conformational plasticity of the peptide in recognizing the NPY receptors. The N terminus of the peptide forms extensive interactions with the Y₁ receptor, but not with the Y₂ and Y₄ receptors. Sup

SUBMITTER: Tang T 

PROVIDER: S-EPMC9067930 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature