Genetic polymorphisms associated with endothelial function in nonarteritic anterior ischemic optic neuropathy.

ABSTRACT:

Purpose

To examine the relationship between nonarteritic anterior ischemic optic neuropathy (NAION) and genetic polymorphisms of enzymes influencing endothelial function.

Methods

The subjects were 34 patients with NAION (mean age, 62.4 years old; 59% male) and 102 controls (mean age, 63.8 years old; 66% male). Genetic polymorphisms were investigated in three candidate genes associated with endothelial function: endothelin-1 (ET-1), angiotensin-converting enzyme (ACE), and methylenetetrahydrofolate reductase (MTHFR). The genotype distributions in the patients with NAION were compared with those in the controls.

Results

There were no significant differences in the genotype distributions of the ACE I/D and MTHFR C677T polymorphisms between the NAION and control groups (p

SUBMITTER: Sakai T 

PROVIDER: S-EPMC3566895 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature