Different thresholds of tissue-specific dose-responses to growth hormone in short prepubertal children.

ABSTRACT:

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Background

In addition to stimulating linear growth in children, growth hormone (GH) influences metabolism and body composition. These effects should be considered when individualizing GH treatment as dose-dependent changes in metabolic markers have been reported.

Hypothesis

There are different dose-dependent thresholds for metabolic effects in response to GH treatment.

Method

A randomized, prospective, multicentre trial TRN 98-0198-003 was performed for a 2-year catch-up growth period, with two treatment regimens (a) individualized GH dose including six different dose groups ranging from 17-100 μg/kg/day (n=87) and (b) fixed GH dose of 43 μg/kg/day (n=41). The individualized GH dose group was used for finding dose-response effects, where the effect

SUBMITTER: Decker R 

PROVIDER: S-EPMC3583138 | biostudies-literature | 2012 Nov

REPOSITORIES: biostudies-literature