Hit identification of IKKβ natural product inhibitor.

ABSTRACT:

Background

The nuclear factor-κB (NF-κB) proteins are a small group of heterodimeric transcription factors that play an important role in regulating the inflammatory, immune, and apoptotic responses. NF-κB activity is suppressed by association with the inhibitor IκB. Aberrant NF-κB signaling activity has been associated with the development of cancer, chronic inflammatory diseases and auto-immune diseases. The IKK protein complex is comprised of IKKα, IKKβ and NEMO subunits, with IKKβ thought to play the dominant role in modulating NF-κB activity. Therefore, the discovery of new IKKβ inhibitors may offer new therapeutic options for the treatment of cancer and inflammatory diseases.

Results

A structure-based molecular docking approach has been employed to discover novel IKKβ

SUBMITTER: Leung CH 

PROVIDER: S-EPMC3583241 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature