Ontology highlight
ABSTRACT:
SUBMITTER: Foley DJ
PROVIDER: S-EPMC7383971 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Foley Daniel J DJ Zinken Sarah S Corkery Dale D Laraia Luca L Pahl Axel A Wu Yao-Wen YW Waldmann Herbert H
Angewandte Chemie (International ed. in English) 20200421 30
Pseudo-natural-product (NP) design combines natural product fragments to provide unprecedented NP-inspired compounds not accessible by biosynthesis, but endowed with biological relevance. Since the bioactivity of pseudo-NPs may be unprecedented or unexpected, they are best evaluated in target agnostic cell-based assays monitoring entire cellular programs or complex phenotypes. Here, the Cinchona alkaloid scaffold was merged with the indole ring system to synthesize indocinchona alkaloids by Pd-c ...[more]