Ontology highlight
ABSTRACT:
SUBMITTER: Belcher BP
PROVIDER: S-EPMC9934694 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Belcher Bridget P BP Machicao Paulo A PA Tong Binqi B Ho Emily E Friedli Julia J So Brian B Bui Helen H Isobe Yosuke Y Maimone Thomas J TJ Nomura Daniel K DK
bioRxiv : the preprint server for biology 20230211
Chlorinated gymnastatin and dankastatin alkaloids derived from the fungal strain <i>Gymnascella dankaliensis</i> have been reported to possess significant anti-cancer activity but their mode of action is unknown. These members possess electrophilic functional groups that may undergo covalent bond formation with specific proteins to exert their biological activity. To better understand the mechanism of action of this class of natural products, we mapped the proteome-wide cysteine-reactivity of th ...[more]