In vivo mouse cardiac hyperpolarized magnetic resonance spectroscopy.

ABSTRACT:

Background

Alterations in cardiac metabolism accompany many diseases of the heart. The advent of cardiac hyperpolarized magnetic resonance spectroscopy (MRS), via dynamic nuclear polarization (DNP), has enabled a greater understanding of the in vivo metabolic changes that occur as a consequence of myocardial infarction, hypertrophy and diabetes. However, all cardiac studies performed to date have focused on rats and larger animals, whereas more information could be gained through the study of transgenic mouse models of heart disease. Translation from the rat to the mouse is challenging, due in part to the reduced heart size (1/10(th)) and the increased heart rate (50%) in the mouse compared to the rat.

Methods and results

In this study, we have investigated the in vivo metab

SUBMITTER: Dodd MS 

PROVIDER: S-EPMC3599631 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature