The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation.
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ABSTRACT:
SUBMITTER: Alasmari W
PROVIDER: S-EPMC3600839 | biostudies-literature | 2013 Apr
REPOSITORIES: biostudies-literature
Publications
The clinical significance of calcium-signalling pathways mediating human sperm hyperactivation.
Alasmari Wardah W Barratt Christopher L R CL Publicover Stephen J SJ Whalley Katherine M KM Foster Erica E Kay Vanessa V Martins da Silva Sarah S Oxenham Senga K SK
Human reproduction (Oxford, England) 20130212 4
<h4>Study question</h4>What is the prevalence of defects in the Ca(2+)-signalling pathways mediating hyperactivation (calcium influx and store mobilization) among donors and sub-fertile patients and are they functionally significant, i.e. related to fertilization success at IVF?<h4>Summary answer</h4>This study identifies, for the first time, the prevalence of Ca(2+) store defects in sperm from research donors, IVF and ICSI patients. It highlights the biological role and importance of Ca(2+) sig ...[more]
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