Ontology highlight
ABSTRACT:
SUBMITTER: Ekins S
PROVIDER: S-EPMC3607962 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Chemistry & biology 20130301 3
Identification of unique leads represents a significant challenge in drug discovery. This hurdle is magnified in neglected diseases such as tuberculosis. We have leveraged public high-throughput screening (HTS) data to experimentally validate a virtual screening approach employing Bayesian models built with bioactivity information (single-event model) as well as bioactivity and cytotoxicity information (dual-event model). We virtually screened a commercial library and experimentally confirmed ac ...[more]