Alterations in brain transition metals in Huntington disease: an evolving and intricate story.

ABSTRACT:

Background

Aberrant accumulation of transition metals in the brain may have an early and important role in the pathogenesis of several neurodegenerative disorders, including Huntington disease (HD).

Objective

To comprehensively evaluate and validate the distribution of metal deposition in the brain using advanced magnetic resonance imaging methods from the premanifest through symptomatic stages of HD.

Design

Observational study.

Setting

University imaging center.

Participants

Twenty-eight HD expanded gene carriers, 34 patients with symptomatic HD, and 56 age- and sex-matched healthy control subjects were included in the study.

Interventions

Participants underwent magnetic resonance imaging for the quantification of the phase evolution of susceptib

SUBMITTER: Rosas HD 

PROVIDER: S-EPMC3652228 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature