Dataset Information
Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.
Ontology highlight
ABSTRACT: Background
Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms.Purpose
We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks.Methods
This was a dose-response, placebo-controlled, double-blind, randomized, crossover trial (8-week treatment, 6-week washout) in 26 adults.Results
Throughout the testing sessions, HR was reduced in a dose-dependent manner. The high dose reduced BP and stroke volume and increased pre-ejection period. Reductions in BP were associated with increases in erythrocyte omega-3 fatty acids.Conclusions
High-dose long-chain omega-3 fatty acids can reduce BP and HR, at rest and during stress. These findings suggest that at-risk populations may achieve benefits with increased omega-3 intake. The trial was registered on ClinicalTrials.gov (NCT00504309).
SUBMITTER: Skulas-Ray AC
PROVIDER: S-EPMC3653417 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
Effects of marine-derived omega-3 fatty acids on systemic hemodynamics at rest and during stress: a dose-response study.
Annals of behavioral medicine : a publication of the Society of Behavioral Medicine 20121201 3
<h4>Background</h4>Omega-3 fatty acids reduced heart rate (HR) and blood pressure (BP) in some studies, but dose-response studies are rare, and little is known about underlying mechanisms.<h4>Purpose</h4>We examined effects of 0.85 g/day eicosapentaenoic acid (EPA) + docosahexaenoic acid (DHA) (low dose) and 3.4 g/day EPA + DHA (high dose) on HR and systemic hemodynamics during rest, speech, and foot cold pressor tasks.<h4>Methods</h4>This was a dose-response, placebo-controlled, double-blind, r ...[more]